| First Author | Iwakoshi NN | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 4 | Pages | 321-9 |
| PubMed ID | 12612580 | Mgi Jnum | J:215658 |
| Mgi Id | MGI:5605956 | Doi | 10.1038/ni907 |
| Citation | Iwakoshi NN, et al. (2003) Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 4(4):321-9 |
| abstractText | The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, providing an integral link between XBP-1, the UPR and plasma cell differentiation. Signals involved in plasma cell differentiation, specifically interleukin-4, control the transcription of XBP-1, whereas its post-transcriptional processing is dependent on synthesis of immunoglobulins during B cell differentiation. We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR. |
