| First Author | Tanaka Y | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 7 | Pages | 1579-86 |
| PubMed ID | 15757644 | Mgi Jnum | J:97383 |
| Mgi Id | MGI:3575355 | Doi | 10.1016/j.febslet.2005.01.068 |
| Citation | Tanaka Y, et al. (2005) The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. FEBS Lett 579(7):1579-86 |
| abstractText | Activation of angiotensin II (Ang II) type 1 receptor (AT1R) signaling is reported to play an important role in cardiac hypertrophy. We previously cloned a novel molecule interacting with the AT1R, which we named ATRAP (for Ang II type 1 receptor-associated protein). Here, we report that overexpression of ATRAP significantly decreases the number of AT1R on the surface of cardiomyocytes, and also decreases the degree of p38 mitogen-activated protein kinase phosphorylation, the activity of the c-fos promoter and protein synthesis upon Ang II treatment. These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes. |
