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Publication : Isolation, cloning, and expression of a new murine zinc finger encoding gene.

First Author  Prost JF Year  1999
Journal  Biochim Biophys Acta Volume  1447
Issue  2-3 Pages  278-83
PubMed ID  10542327 Mgi Jnum  J:66304
Mgi Id  MGI:1928248 Doi  10.1016/s0167-4781(99)00157-8
Citation  Prost JF, et al. (1999) Isolation, cloning, and expression of a new murine zinc finger encoding gene. Biochim Biophys Acta 1447(2-3):278-83
abstractText  With the aim of identifying genes involved in cartilage differentiation, we have used a subtractive hybridization strategy with cDNAs from a chondrocytic cell line (MC615) and mRNAs from a mesenchymal precursor cell line (10T1/2). We have isolated a cDNA clone representing a novel mouse gene. The predicted 368-amino acid protein, designated ZF-12, contains four C(2)H(2)-type zinc finger motifs and one region homologous to the LeR domain, a finger-associated structural domain. ZF-12 mRNAs are expressed during embryonic development and in different organs in adult, including rib cartilage. These data suggest that ZF-12 might play an important role not only in cartilage differentiation, but also in basic cellular processes.
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