First Author | Prost JF | Year | 1999 |
Journal | Biochim Biophys Acta | Volume | 1447 |
Issue | 2-3 | Pages | 278-83 |
PubMed ID | 10542327 | Mgi Jnum | J:66304 |
Mgi Id | MGI:1928248 | Doi | 10.1016/s0167-4781(99)00157-8 |
Citation | Prost JF, et al. (1999) Isolation, cloning, and expression of a new murine zinc finger encoding gene. Biochim Biophys Acta 1447(2-3):278-83 |
abstractText | With the aim of identifying genes involved in cartilage differentiation, we have used a subtractive hybridization strategy with cDNAs from a chondrocytic cell line (MC615) and mRNAs from a mesenchymal precursor cell line (10T1/2). We have isolated a cDNA clone representing a novel mouse gene. The predicted 368-amino acid protein, designated ZF-12, contains four C(2)H(2)-type zinc finger motifs and one region homologous to the LeR domain, a finger-associated structural domain. ZF-12 mRNAs are expressed during embryonic development and in different organs in adult, including rib cartilage. These data suggest that ZF-12 might play an important role not only in cartilage differentiation, but also in basic cellular processes. |