| First Author | Ducker CE | Year | 2004 |
| Journal | Oncogene | Volume | 23 |
| Issue | 57 | Pages | 9230-7 |
| PubMed ID | 15489887 | Mgi Jnum | J:94960 |
| Mgi Id | MGI:3522376 | Doi | 10.1038/sj.onc.1208171 |
| Citation | Ducker CE, et al. (2004) Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene 23(57):9230-7 |
| abstractText | Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug design due to their pivotal roles in the subcellular localization of a number of oncogenes. We show that the Huntingtin interacting protein 14 (HIP14) is a PAT with a preference for the farnesyl-dependent palmitoylation motif found in H- and N-RAS. Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice. Activity of the enzyme and its ability to transform cells is dependent on critical residues in the active site of the enzyme. |
