| First Author | Palmer S | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 22 | Pages | 12030-5 |
| PubMed ID | 9342357 | Mgi Jnum | J:43704 |
| Mgi Id | MGI:1098365 | Doi | 10.1073/pnas.94.22.12030 |
| Citation | Palmer S, et al. (1997) A gene spans the pseudoautosomal boundary in mice. Proc Natl Acad Sci U S A 94(22):12030-5 |
| abstractText | The X and Y chromosomes of the mouse, like those of other mammals, are heteromorphic over most of their length, but at the distal ends of the chromosomes is a region of sequence identity, the pseudoautosomal region (PAR), where the chromosomes pair and recombine during male meiosis. The point at which the PAR diverges into X- and Y-specific sequences is called the pseudoautosomal boundary. We have completed a genomic walk from the X-specific Amelogenin gene to the PAR, Analysis of this region revealed that the pseudoautosomal boundary of mice is located within an intron of a transcribed gene that encodes a novel RING finger protein. The first three of the exons of the gene are located on the ii chromosome whereas the 3' exons of the gene are located on both X and Y chromosomes. This unusual arrangement may indicate that the gene is in a state of transition from pseudoautosomal to X-unique and provides evidence for a process of attrition of the pseudoautosomal region on the Y chromosome. |
