| First Author | Chowdhury K | Year | 1987 |
| Journal | Cell | Volume | 48 |
| Issue | 5 | Pages | 771-8 |
| PubMed ID | 3815523 | Mgi Jnum | J:8590 |
| Mgi Id | MGI:57056 | Doi | 10.1016/0092-8674(87)90074-2 |
| Citation | Chowdhury K, et al. (1987) A multigene family encoding several finger structures is present and differentially active in mammalian genomes. Cell 48(5):771-8 |
| abstractText | Mouse genomic DNA contains multiple copies of sequences homologous to the Drosophila Kruppel, a member of the gap class of developmental control genes of the fruit fly. The most interesting aspect of the homologous region is that, like Xenopus TFIIIA, it contains multiple finger-like folded domains capable of binding to nucleic acids. We have isolated six individual phages from a mouse genomic library on the basis of their DNA homology to Kruppel finger-coding probes, and describe here the DNA sequence and expression of two such clones containing finger-like structures. Upon differentiation of mouse teratocarcinoma cell line F9 with retinoic acid and cAMP, the expression of both genes was drastically reduced, and in one instance was undetectable. Each of the several other eukaryotic DNAs analyzed contained multiple copies of homologous genes with putative finger structures, indicating the presence of a finger-containing multigene family in higher organisms. |
