| First Author | Komine Y | Year | 2006 |
| Journal | Mol Cell Neurosci | Volume | 31 |
| Issue | 2 | Pages | 273-83 |
| PubMed ID | 16257534 | Mgi Jnum | J:106421 |
| Mgi Id | MGI:3618541 | Doi | 10.1016/j.mcn.2005.09.017 |
| Citation | Komine Y, et al. (2006) Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain. Mol Cell Neurosci 31(2):273-83 |
| abstractText | Here, we report features of a novel transcription factor zfh-5, which we isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA. Although most neurons express zfh-5 mRNA soon after their final mitosis, several types of neurons, such as the pyramidal and granule cells in the hippocampus, express the zfh-5 antisense RNA prior to the mRNA expression. Using gene-targeting approach, we showed that this antisense RNA has a negative regulatory role on the expression of zfh-5 mRNA. These observations suggest that, in specific types of neurons, the expression of zfh-5 is additionally regulated by a mechanism depending on this antisense RNA. |
