| First Author | Suzuki A | Year | 1994 |
| Journal | FEBS Lett | Volume | 355 |
| Issue | 1 | Pages | 19-22 |
| PubMed ID | 7957954 | Mgi Jnum | J:21736 |
| Mgi Id | MGI:69653 | Doi | 10.1016/0014-5793(94)01156-7 |
| Citation | Suzuki A, et al. (1994) Cloning of an isoform of mouse TGF-beta type II receptor gene. FEBS Lett 355(1):19-22 |
| abstractText | A variant of transforming growth factor-beta type II receptor (TGF-beta RII) cDNA was isolated from a mouse brain cDNA library. The predicted receptor is identical to previously reported mouse TGF-beta RII except that the isoform has an insertion sequence of 25 amino acids in the predicted ligand-binding domain. By the use of reverse transcription-polymerase chain reaction (RT-PCR), transcripts for both isoforms were detected in all tissues and developing embryos examined. The isoform transiently expressed in COS cells showed a similar ligand-binding specificity to authentic TGF-beta RII. These results suggest that the mouse TGF-beta RII gene generates multiple isoforms, possibly by alternative splicing, as reported for activin type IIB receptor; and an isoform which has the extra sequence in the ligand-binding domain is also involved in the TGF-beta signal transduction. |
