| First Author | Kim MH | Year | 2002 |
| Journal | Mech Dev | Volume | 118 |
| Issue | 1-2 | Pages | 171-4 |
| PubMed ID | 12351182 | Mgi Jnum | J:79510 |
| Mgi Id | MGI:2388423 | Doi | 10.1016/s0925-4773(02)00238-1 |
| Citation | Kim MH, et al. (2002) Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains. Mech Dev 118(1-2):171-4 |
| abstractText | Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell-cell recognition and signalling. We report here that type I SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus, SEZ-6 appears to be a CA1-specific regional marker. |
