| First Author | Hu CJ | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 4 | Pages | 545-55 |
| PubMed ID | 11672537 | Mgi Jnum | J:93128 |
| Mgi Id | MGI:3056007 | Doi | 10.1016/s1074-7613(01)00219-9 |
| Citation | Hu CJ, et al. (2001) PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity 15(4):545-55 |
| abstractText | PU.1(+/-)Spi-B(-/-) mice exhibit reduced numbers of immature and mature B lymphocytes, which exhibit severe defects in response to BCR-mediated stimulation and poor survival. We found that expression of c-rel, a member of the Rel/NF-kappa B family, is dramatically reduced in PU.1(+/-)Spi-B(-/-) splenic B cells. Analysis of the murine c-rel promoter identified three PU.1/Spi-B binding sites critical for c-rel promoter activity. Furthermore, reintroduction of Rel protein restored wild-type B cell numbers to mice reconstituted with PU.1(+/-)Spi-B(-/-) bone marrow. These findings are the first to demonstrate that a member of the Rel/NF-kappa B family is directly regulated by Ets proteins and dissect the molecular basis for the function of two Ets factors, PU.1 and Spi-B, in promoting B lymphocyte survival. |
