| First Author | Jarriault S | Year | 1995 |
| Journal | Nature | Volume | 377 |
| Issue | 6547 | Pages | 355-8 |
| PubMed ID | 7566092 | Mgi Jnum | J:28945 |
| Mgi Id | MGI:76482 | Doi | 10.1038/377355a0 |
| Citation | Jarriault S, et al. (1995) Signalling downstream of activated mammalian Notch [see comments]. Nature 377(6547):355-8 |
| abstractText | Notch belongs to a family of transmembrane proteins that are widely conserved from flies to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the Suppressor of hairless (Su(H)) gene and genes of the Enhancer of split (E(Spl)) complex, which encode proteins of the basic helix-loop-helix type have been implicated in the Notch signalling pathway. Mammalian homologues of E(Spl), such as the mouse Hairy enhancer of split (HES-1), have been isolated. Both HES-1 and the intracellular domain of murine Notch (mNotch) are able to block MyoD-induced myogenesis. Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
