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Publication : A mouse TGF-beta type I receptor that requires type II receptor for ligand binding.

First Author  Suzuki A Year  1994
Journal  Biochem Biophys Res Commun Volume  198
Issue  3 Pages  1063-9
PubMed ID  8117262 Mgi Jnum  J:16862
Mgi Id  MGI:64921 Doi  10.1006/bbrc.1994.1151
Citation  Suzuki A, et al. (1994) A mouse TGF-beta type I receptor that requires type II receptor for ligand binding. Biochem Biophys Res Commun 198(3):1063-9
abstractText  A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.
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