| First Author | Kikuchi K | Year | 1999 |
| Journal | Mol Cell Neurosci | Volume | 13 |
| Issue | 1 | Pages | 9-23 |
| PubMed ID | 10049528 | Mgi Jnum | J:53334 |
| Mgi Id | MGI:1332309 | Doi | 10.1006/mcne.1998.0732 |
| Citation | Kikuchi K, et al. (1999) Cloning and characterization of a novel class VI semaphorin, semaphorin Y. Mol Cell Neurosci 13(1):9-23 |
| abstractText | Semaphorins comprise a large family of proteins implicated in axonal guidance. We cloned a novel transmembrane semaphorin, semaphorin Y (Sema Y), which has a class VI sema domain. Sema Y shows growth cone collapsing activity on DRG neurons in vitro, and the target regions of the DRG neurons express sema Y mRNA during development. Sema Y may be a stop signal for these neurons in their target areas. Interestingly, sema Y mRNA was also detected in other neurons and their targets. Two isoforms of Sema Y derived from alternative splicing were identified and their expression was found to be regulated in a tissue- and age-dependent manner. Distribution of sema Y mRNA suggests that Sema Y might also be important during maintenance of axonal connections and/or differentiation and migration of cells. Sequence comparison among class VI semaphorins revealed two short conserved sequence stretches in their cytoplasmic domains, suggesting interaction of these semaphorins with a common intracellular component(s). Copyright 1999 Academic Press. |
