| First Author | Oh B | Year | 1997 |
| Journal | Development | Volume | 124 |
| Issue | 2 | Pages | 493-503 |
| PubMed ID | 9053325 | Mgi Jnum | J:38386 |
| Mgi Id | MGI:85757 | Doi | 10.1242/dev.124.2.493 |
| Citation | Oh B, et al. (1997) Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo. Development 124(2):493-503 |
| abstractText | Timely translation of maternal transcripts and post-translational modification of their gene products control the initial development of preimplantation-stage embryos. We have isolated and characterized a gene encoding a stage-specific embryonic protein. This novel gene, spindlin (Spin), is an abundant maternal transcript present in the unfertilized egg and 2-cell, but not 8-cell, stage embryo. Spin exhibits high homology to a multicopy gene, Y-linked spermiogenesis-specific transcript (Ssty), and together they form a new gene family expressed during gametogenesis. We find that spindlin associates with the meiotic spindle and is modified by phosphorylation in a cell-cycle-dependent fashion. Furthermore, it comigrates with the previously described 30x10(3) Mr metaphase complex which is posttranslationally modified during the first mitotic cell cycle. Our data suggest that spindlin plays a role in cell-cycle regulation during the transition from gamete to embryo. |
