| First Author | Galloway A | Year | 2016 |
| Journal | Science | Volume | 352 |
| Issue | 6284 | Pages | 453-9 |
| PubMed ID | 27102483 | Mgi Jnum | J:232475 |
| Mgi Id | MGI:5779430 | Doi | 10.1126/science.aad5978 |
| Citation | Galloway A, et al. (2016) RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. Science 352(6284):453-9 |
| abstractText | Progression through the stages of lymphocyte development requires coordination of the cell cycle. Such coordination ensures genomic integrity while cells somatically rearrange their antigen receptor genes [in a process called variable-diversity-joining (VDJ) recombination] and, upon successful rearrangement, expands the pools of progenitor lymphocytes. Here we show that in developing B lymphocytes, the RNA-binding proteins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for reestablishing quiescence after pre-BCR-induced expansion. These RBPs suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle. This mechanism promotes VDJ recombination and effective selection of cells expressing immunoglobulin-mu at the pre-BCR checkpoint. |
