| First Author | Nishijima I | Year | 2006 |
| Journal | Hum Mol Genet | Volume | 15 |
| Issue | 21 | Pages | 3241-50 |
| PubMed ID | 17008357 | Mgi Jnum | J:114853 |
| Mgi Id | MGI:3690260 | Doi | 10.1093/hmg/ddl402 |
| Citation | Nishijima I, et al. (2006) Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Hum Mol Genet 15(21):3241-50 |
| abstractText | Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior. |
