| First Author | Mountjoy KG | Year | 1992 |
| Journal | Science | Volume | 257 |
| Issue | 5074 | Pages | 1248-51 |
| PubMed ID | 1325670 | Mgi Jnum | J:2164 |
| Mgi Id | MGI:50688 | Doi | 10.1126/science.1325670 |
| Citation | Mountjoy KG, et al. (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257(5074):1248-51 |
| abstractText | Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor. |
