| First Author | Goverman J | Year | 1985 |
| Journal | Cell | Volume | 40 |
| Issue | 4 | Pages | 859-67 |
| PubMed ID | 2580639 | Mgi Jnum | J:7806 |
| Mgi Id | MGI:56275 | Doi | 10.1016/0092-8674(85)90345-9 |
| Citation | Goverman J, et al. (1985) Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction. Cell 40(4):859-67 |
| abstractText | The helper T cell clone 3H.25 is specific for hen egg white lysozyme and the class II MHC molecule I-Ab. This TH cell has three rearrangements in the beta-chain gene family-a V beta-D beta-J beta 1 and a D beta 2-J beta 2 rearrangement on one homolog and a D beta 1-J beta 2 rearrangement on the other. These observations demonstrate that this functional T lymphocyte expresses only a single V beta gene segment and, accordingly, exhibits allelic exclusion of beta-chain gene expression. The rearranged 3H.25 V beta gene segment is the same as that expressed in a T helper cell specific for cytochrome c and an I-Ek MHC molecule. Thus, there is no simple correlation between the V beta gene segment and antigen specificity or MHC restriction. |
