| First Author | Migone TS | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 3 | Pages | 479-92 |
| PubMed ID | 11911831 | Mgi Jnum | J:75557 |
| Mgi Id | MGI:2177063 | Doi | 10.1016/s1074-7613(02)00283-2 |
| Citation | Migone TS, et al. (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16(3):479-92 |
| abstractText | DR3 is a death domain-containing receptor that is upregulated during T cell activation and whose overexpression induces apoptosis and NF-kappaB activation in cell lines. Here we show that an endothelial cell-derived TNF-like factor, TL1A, is a ligand for DR3 and decoy receptor TR6/DcR3 and that its expression is inducible by TNF and IL-1alpha. TL1A induces NF-kappaB activation and apoptosis in DR3-expressing cell lines, while TR6-Fc protein antagonizes these signaling events. Interestingly, in T cells, TL1A acts as a costimulator that increases IL-2 responsiveness and secretion of proinflammatory cytokines both in vitro and in vivo. Our data suggest that interaction of TL1A with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect. |
