| First Author | Wiley SR | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 6 | Pages | 673-82 |
| PubMed ID | 8777713 | Mgi Jnum | J:30253 |
| Mgi Id | MGI:77767 | Doi | 10.1016/1074-7613(95)90057-8 |
| Citation | Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3(6):673-82 |
| abstractText | A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin. |
