| First Author | Bell SE | Year | 2006 |
| Journal | Dev Dyn | Volume | 235 |
| Issue | 11 | Pages | 3144-55 |
| PubMed ID | 17013884 | Mgi Jnum | J:113396 |
| Mgi Id | MGI:3686540 | Doi | 10.1002/dvdy.20949 |
| Citation | Bell SE, et al. (2006) The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn 235(11):3144-55 |
| abstractText | The Zfp36l1 gene encodes a zinc finger-containing mRNA binding protein implicated in the posttranscriptional control of gene expression. Mouse embryos homozygous for a targeted mutation in the Zfp36l1 locus died mid-gestation and exhibited extraembryonic and intraembryonic vascular abnormalities and heart defects. In the developing placenta, there was a failure of the extraembryonic mesoderm to invaginate the trophoblast layer. The phenotype was associated with an elevated expression of vascular endothelial growth factor (VEGF)-A in the embryos and in embryonic fibroblasts cultured under conditions of both normoxia and hypoxia. VEGF-A overproduction by embryonic fibroblasts was not a consequence of changes in Vegf-a mRNA stability; instead, we observed enhanced association with polyribosomes, suggesting Zfp36l1 influences translational regulation. These data implicate Zfp36l1as a negative regulator of Vegf-a gene activity during development. Developmental Dynamics 235:3144-3155, 2006. (c) 2006 Wiley-Liss, Inc. |
