| First Author | Sornson MW | Year | 1996 |
| Journal | Nature | Volume | 384 |
| Issue | 6607 | Pages | 327-33 |
| PubMed ID | 8934515 | Mgi Jnum | J:36967 |
| Mgi Id | MGI:84377 | Doi | 10.1038/384327a0 |
| Citation | Sornson MW, et al. (1996) Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384(6607):327-33 |
| abstractText | The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis. |
