| First Author | Horng T | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 9 | Pages | 835-41 |
| PubMed ID | 11526399 | Mgi Jnum | J:72250 |
| Mgi Id | MGI:2152194 | Doi | 10.1038/ni0901-835 |
| Citation | Horng T, et al. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2(9):835-41 |
| abstractText | Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. Although some cellular responses are completely abolished in MyD88-deficient mice, TLR4, but not TLR9, can activate NF-kappa B and mitogen-activated protein kinases and induce dendritic cell maturation in the absence of MyD88. These differences suggest that another adapter must exist that can mediate MyD88-independent signaling in response to TLR4 ligation. We have identified and characterized a Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) and have shown that it controls activation of MyD88-independent signaling pathways downstream of TLR4. We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways. |
