| First Author | Simmler MC | Year | 1996 |
| Journal | Hum Mol Genet | Volume | 5 |
| Issue | 11 | Pages | 1713-26 |
| PubMed ID | 8922998 | Mgi Jnum | J:36484 |
| Mgi Id | MGI:83911 | Doi | 10.1093/hmg/5.11.1713 |
| Citation | Simmler MC, et al. (1996) A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx. Hum Mol Genet 5(11):1713-26 |
| abstractText | X chromosome inactivation in both mouse and human requires the presence of a cis acting locus, the X inactivation centre. This locus is thought to be involved in the initiation and spreading of the inactivation signal in early development. In order to increase our understanding of the mouse X inactivation centre, a 94 kb region immediately distal to the Xist gene has been sequenced and analysed for the presence of transcription units and/or potential cis acting regulatory elements. We have identified a novel gene, Tsx, lying 40 kb 3' from Xist. Tsx is expressed specifically in the testis and shows no convincing homology to proteins currently in the databases, A rat homologue, also X linked, has been isolated, The mouse and rat Tsx sequences are highly divergent, suggesting that part of the X inactivation centre, including both Xist and Tsx are subject to relatively weak evolutionary constraints. |
