| First Author | Karaghiosoff M | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 4 | Pages | 549-60 |
| PubMed ID | 11070173 | Mgi Jnum | J:65408 |
| Mgi Id | MGI:1926544 | Doi | 10.1016/s1074-7613(00)00054-6 |
| Citation | Karaghiosoff M, et al. (2000) Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13(4):549-60 |
| abstractText | To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where inactivation leads to a complete loss of the respective cytokine receptor signal, Tyk2-/- mice display reduced responses to IFNalpha/beta and IL-12 and a selective deficiency in Stat3 activation in these pathways. Unexpectedly, IFNgamma signaling is also impaired in Tyk2-/- mice. Tyk2-/- macrophages fail to produce nitric oxide upon lipopolysaccharide induction. Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge. These data imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors. |
