First Author | Kubota H | Year | 1997 |
Journal | FEBS Lett | Volume | 402 |
Issue | 1 | Pages | 53-6 |
PubMed ID | 9013858 | Mgi Jnum | J:38115 |
Mgi Id | MGI:85502 | Doi | 10.1016/s0014-5793(96)01501-3 |
Citation | Kubota H, et al. (1997) Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. FEBS Lett 402(1):53-6 |
abstractText | We have cloned a novel Tcp-1-related mouse testis cDNA encoding a polypeptide of 531 amino acids which shares 81.2% identity with the zeta subunit of the mouse cytosolic chaperonin-containing TCP-1 (CCT). Immunoblot analysis of mouse testis CCT subunits separated by 2-dimensional gel electrophoresis indicates that this novel gene, Cctz-2, encodes a CCT subunit of Mr 57 000 and pI 7.1. Cctz-2 mRNA is detected only in testis whereas the other Cctz gene, Cctz-1, is expressed in all tissues investigated. The CCTzeta-2 subunit may have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones. |