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Publication : Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.

First Author  Kubota H Year  1997
Journal  FEBS Lett Volume  402
Issue  1 Pages  53-6
PubMed ID  9013858 Mgi Jnum  J:38115
Mgi Id  MGI:85502 Doi  10.1016/s0014-5793(96)01501-3
Citation  Kubota H, et al. (1997) Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. FEBS Lett 402(1):53-6
abstractText  We have cloned a novel Tcp-1-related mouse testis cDNA encoding a polypeptide of 531 amino acids which shares 81.2% identity with the zeta subunit of the mouse cytosolic chaperonin-containing TCP-1 (CCT). Immunoblot analysis of mouse testis CCT subunits separated by 2-dimensional gel electrophoresis indicates that this novel gene, Cctz-2, encodes a CCT subunit of Mr 57 000 and pI 7.1. Cctz-2 mRNA is detected only in testis whereas the other Cctz gene, Cctz-1, is expressed in all tissues investigated. The CCTzeta-2 subunit may have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones.
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