| First Author | Leco KJ | Year | 1997 |
| Journal | FEBS Lett | Volume | 401 |
| Issue | 2-3 | Pages | 213-7 |
| PubMed ID | 9013889 | Mgi Jnum | J:38132 |
| Mgi Id | MGI:85519 | Doi | 10.1016/s0014-5793(96)01474-3 |
| Citation | Leco KJ, et al. (1997) Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. FEBS Lett 401(2-3):213-7 |
| abstractText | We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide sequence predicts a protein of 22,609 Da that contains the characteristic 12 cysteine TIMP signature. TIMP-4 is more closely related to TIMP-2 and TIMP-3 than to TIMP-1 (48%, 45% and 38% identity, respectively). Analysis of Timp-4 mRNA expression in adult mouse tissues indicated a 1.2 kb transcript in brain, heart, ovary and skeletal muscle. This pattern of expression distinguishes Timp-4 from other Timps, suggesting that the TIMP-4 protein may be an important tissue-specific regulator of extracellular matrix remodelling. |
