| First Author | Butler A | Year | 1993 |
| Journal | Science | Volume | 261 |
| Issue | 5118 | Pages | 221-4 |
| PubMed ID | 7687074 | Mgi Jnum | J:13395 |
| Mgi Id | MGI:61591 | Doi | 10.1126/science.7687074 |
| Citation | Butler A, et al. (1993) mSlo, a complex mouse gene encoding maxi calcium-activated potassium channels. Science 261(5118):221-4 |
| abstractText | Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled maxi or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene. |
