| First Author | Krendel M | Year | 2009 |
| Journal | J Am Soc Nephrol | Volume | 20 |
| Issue | 1 | Pages | 86-94 |
| PubMed ID | 19005011 | Mgi Jnum | J:159163 |
| Mgi Id | MGI:4441423 | Doi | 10.1681/ASN.2007111172 |
| Citation | Krendel M, et al. (2009) Disruption of Myosin 1e promotes podocyte injury. J Am Soc Nephrol 20(1):86-94 |
| abstractText | Myosin 1e (Myo1e) is one of two Src homology 3 domain-containing 'long-tailed' type I myosins in vertebrates, whose functions in health and disease are incompletely understood. Here, we demonstrate that Myo1e localizes to podocytes in the kidney. We generated Myo1e-knockout mice and found that they exhibit proteinuria, signs of chronic renal injury, and kidney inflammation. At the ultrastructural level, renal tissue from Myo1e-null mice demonstrates changes characteristic of glomerular disease, including a thickened and disorganized glomerular basement membrane and flattened podocyte foot processes. These observations suggest that Myo1e plays an important role in podocyte function and normal glomerular filtration. |
