| First Author | Tokoro Y | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 288 |
| Issue | 1 | Pages | 178-83 |
| PubMed ID | 11594770 | Mgi Jnum | J:72432 |
| Mgi Id | MGI:2152669 | Doi | 10.1006/bbrc.2001.5742 |
| Citation | Tokoro Y, et al. (2001) Molecular cloning and characterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells. Biochem Biophys Res Commun 288(1):178-83 |
| abstractText | Dendritic cells (DCs) are the most potent antigen-presenting cells and play an essential role for triggering T-cell-mediated immune responses. In search for novel cell surface molecules expressed on DCs involved in T cell priming by representational differential analysis, we identified a mouse homologue of Tspan-3 (mTspan-3), a novel member of the tetraspanin superfamily. The mTspan-3 consists of four hydrophobic, putative transmembrane regions, forming a small and a large extracellular loop, with short intracellular amino and carboxil tails. Although the mTspan-3 is expressed on a variety of immune cell types including resting DCs, its expression on DCs is downregulated during activation induced by cross-linking CD40 with anti-CD40 monoclonal antibody. These results suggest that mTspan-3 may be involved in the function of DCs in association with T cell stimulation. |
