| First Author | Aguado E | Year | 2002 |
| Journal | Science | Volume | 296 |
| Issue | 5575 | Pages | 2036-40 |
| PubMed ID | 12065839 | Mgi Jnum | J:77098 |
| Mgi Id | MGI:2180996 | Doi | 10.1126/science.1069057 |
| Citation | Aguado E, et al. (2002) Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296(5575):2036-40 |
| abstractText | The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor (TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT tyrosine residue showed impeded T cell development. However, later they accumulated polyclonal helper T (TH) cells that chronically produced type 2 cytokines in large amounts. This exaggerated TH2 differentiation caused tissue eosinophilia and massive maturation of plasma cells secreting to immunoglobulins of the E and G1 isotypes. This paradoxical phenotype establishes an unanticipated inhibitory function for LAT that is critical for the differentiation and homeostasis of TH cells. |
