| First Author | Zhang L | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 400 |
| Issue | 4 | Pages | 696-700 |
| PubMed ID | 20816665 | Mgi Jnum | J:165584 |
| Mgi Id | MGI:4837785 | Doi | 10.1016/j.bbrc.2010.08.130 |
| Citation | Zhang L, et al. (2010) A novel ncRNA gene from mouse chromosome 5 trans-splices with Dmrt1 on chromosome 19. Biochem Biophys Res Commun 400(4):696-700 |
| abstractText | Dmrt1 (Dsx- and Mab3-related transcription factor-1), a conserved transcription factor in different phyla, is a key regulator in sex determination. Here, we report the novel ncRNA gene Dmr (Dmrt1-related gene), from mouse chromosome 5 that trans-splices with Dmrt1 from chromosome 19 to generate a Dmrt1 protein that lacks the C-terminus. Dmr is mouse and rat specific, and the surrounding genes are also conserved in both species. Dmr is alternatively spliced, and three isoforms, Dmr a, b and c, are detected in the testis. Further, Dmr serves mainly as a 3' UTR, promotes trans-splicing and down-regulates the Dmrt1 protein. These results suggest that Dmr might play a negative regulatory role for Dmrt1 in male sexual development. |
