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Publication : A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.

First Author  Chien YH Year  1987
Journal  Nature Volume  327
Issue  6124 Pages  677-82
PubMed ID  2439914 Mgi Jnum  J:8772
Mgi Id  MGI:57237 Doi  10.1038/327677a0
Citation  Chien YH, et al. (1987) A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 327(6124):677-82
abstractText  A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.
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