| First Author | Neilan EG | Year | 1999 |
| Journal | Transgenic Res | Volume | 8 |
| Issue | 6 | Pages | 451-8 |
| PubMed ID | 10767988 | Mgi Jnum | J:61436 |
| Mgi Id | MGI:1354987 | Doi | 10.1023/a:1008928925142 |
| Citation | Neilan EG, et al. (1999) Gene trap insertional mutagenesis in mice: new vectors and germ line mutations in two novel genes. Transgenic Res 8(6):451-8 |
| abstractText | Insertional mutagenesis based on gene trap vectors that capture endogenous splice sites is a promising tool for functional genomics. Several groups have proposed large-scale gene trap screens, but questions remain as to the type of vectors and their design. We report a set of plasmid-encoded gene trap vectors and the disruption of two novel genes. Our results include a comparison of the relative gene trapping efficiencies of two different splice acceptor sequences in ES cells and an analysis of the structure of several gene trap insertions. |
