| First Author | Yang L | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 6 | Pages | 2522-5 |
| PubMed ID | 9058782 | Mgi Jnum | J:47842 |
| Mgi Id | MGI:1289992 | Doi | 10.4049/jimmunol.158.6.2522 |
| Citation | Yang L, et al. (1997) Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus. J Immunol 158(6):2522-5 |
| abstractText | A conserved decamer sequence, AGTGA(T/C)(G/A)TCA, related to the cAMP response element (CRE), is found in the promoter regions of most TCR V beta gene segments. It has been shown to be a critical element for T cell-specific transcriptional regulation of the TCR genes. However, none of the decamer or CRE-binding proteins identified thus far is restricted in its expression to cells of the T cell lineage. Therefore, to find T cell-restricted decamer-binding proteins, we screened thymus cDNA expression libraries using the decamer probe. One of the thymus cDNAs identified, clone pmLY2, a novel spliced variant of CREB, was shown to be preferentially expressed in thymus. Therefore, clone pmLY2 is the first T cell-enriched decamer-binding sequence identified. We hypothesize that this CREB variant may play a role in the developmental regulation of TCR and of other T cell specific genes. |
