| First Author | Manenti G | Year | 2000 |
| Journal | Oncogene | Volume | 19 |
| Issue | 47 | Pages | 5324-8 |
| PubMed ID | 11103933 | Mgi Jnum | J:66185 |
| Mgi Id | MGI:1928106 | Doi | 10.1038/sj.onc.1203916 |
| Citation | Manenti G, et al. (2000) A cancer modifier role for parathyroid hormone-related protein. Oncogene 19(47):5324-8 |
| abstractText | The parathyroid hormone-related protein (PTHrP) gene (Pthlh) maps in the distal region of mouse chromosome 6 that contains a quantitative trait locus associated with genetic predisposition to skin tumorigenesis. Here, we report a genetic polymorphism located in the osteostatin encoding region of the Pthlh gene and that produces Thr/ Pro PTHrP variants. PthlhThr and PthlhPro alleles were significantly linked with resistance and susceptibility to skin carcinogenesis in phenotypically selected Car-R and Car-S outbred mice. Transfection of human NCI-H520 squamous cell carcinoma cells with the PthlhPro allele resulted in cells growing in clusters, tending to pile up, and growing at a significantly faster rate in nude mice than non-transfected and PthlhThr-transfected cells. These results point to the role of the Pthlh gene as a cancer modifier gene in skin tumorigenesis. |
