| description | Viral protein involved in the evasion of the type I and III interferon pathway by inhibiting the interferon regulatory factor-9 (IRF9) protein. Viral infection triggers the phosphorylation and activation of IRF9. The activated IRF9 migrates to the nucleus leading to the transcriptional activation of several hundred IFN-responsive genes Some viral proteins inhibit IRF9 activation by preventing its nuclear localization upon infection or by sending it to the nucleus in an inactive state |
