| First Author | Hanks SK | Year | 1995 |
| Journal | FASEB J | Volume | 9 |
| Issue | 8 | Pages | 576-96 |
| PubMed ID | 7768349 | Mgi Jnum | J:25921 |
| Mgi Id | MGI:73624 | Doi | 10.1096/fasebj.9.8.7768349 |
| Citation | Hanks SK, et al. (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9(8):576-96 |
| abstractText | The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase domains (also known as catalytic domains), which consist of approximately 250-300 amino acid residues. The kinase domains that define this group of enzymes contain 12 conserved subdomains that fold into a common catalytic core structure, as revealed by the 3-dimensional structures of several protein-serine kinases. There are two main subdivisions within the superfamily: the protein-serine/threonine kinases and the protein-tyrosine kinases. A classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation. |
