| First Author | Nold MF | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 11 | Pages | 1014-22 |
| PubMed ID | 20935647 | Mgi Jnum | J:166536 |
| Mgi Id | MGI:4847990 | Doi | 10.1038/ni.1944 |
| Citation | Nold MF, et al. (2010) IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 11(11):1014-22 |
| abstractText | The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. Anti-inflammatory cytokines were unaffected. Mice with transgenic expression of IL-37 were protected from lipopolysaccharide-induced shock, and showed markedly improved lung and kidney function and reduced liver damage after treatment with lipopolysaccharide. Transgenic mice had lower concentrations of circulating and tissue cytokines (72-95% less) than wild-type mice and showed less dendritic cell activation. IL-37 interacted intracellularly with Smad3 and IL-37-expressing cells and transgenic mice showed less cytokine suppression when endogenous Smad3 was depleted. IL-37 thus emerges as a natural suppressor of innate inflammatory and immune responses. |
