| First Author | Fatica A | Year | 2003 |
| Journal | Mol Cell Biol | Volume | 23 |
| Issue | 5 | Pages | 1798-807 |
| PubMed ID | 12588997 | Mgi Jnum | J:82336 |
| Mgi Id | MGI:2652305 | Doi | 10.1128/MCB.23.5.1798-1807.2003 |
| Citation | Fatica A, et al. (2003) Nob1p is required for cleavage of the 3' end of 18S rRNA. Mol Cell Biol 23(5):1798-807 |
| abstractText | We report the characterization of a novel factor, Nob1p (Yor056c), which is essential for the synthesis of 40S ribosome subunits. Genetic depletion of Nob1p strongly inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, leading to the accumulation of high levels of the 20S pre-rRNA together with novel degradation intermediates. 20S processing occurs within a pre-40S particle after its export from the nucleus to the cytoplasm. Consistent with a direct role in this cleavage, Nob1p was shown to be associated with the pre-40S particle and to be present in both the nucleus and the cytoplasm. This suggests that Nob1p accompanies the pre-40S ribosomes during nuclear export. Pre-40S export is not, however, inhibited by depletion of Nob1p. |
