| First Author | Tosoni D | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 2 | Pages | 293-300 |
| PubMed ID | 19116150 | Mgi Jnum | J:144201 |
| Mgi Id | MGI:3830421 | Doi | 10.1016/j.febslet.2008.12.047 |
| Citation | Tosoni D, et al. (2009) CAP (Cbl associated protein) regulates receptor-mediated endocytosis. FEBS Lett 583(2):293-300 |
| abstractText | CAP (c-Cbl associated protein)/ponsin belongs to a family of adaptor proteins implicated in cell adhesion and signaling. Here we show that CAP binds to and co-localizes with the essential endocytic factor dynamin. We demonstrate that CAP promotes the formation of dynamin-decorated tubule like structures, which are also coated with actin filaments. Accordingly, we found that the expression of CAP leads to the inhibition of dynamin-mediated endocytosis and increases EGFR stability. Thus, we suggest that CAP may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis. |
