| First Author | Roose J | Year | 1999 |
| Journal | Genomics | Volume | 57 |
| Issue | 2 | Pages | 301-5 |
| PubMed ID | 10198172 | Mgi Jnum | J:54488 |
| Mgi Id | MGI:1335962 | Doi | 10.1006/geno.1999.5779 |
| Citation | Roose J, et al. (1999) The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Genomics 57(2):301-5 |
| abstractText | We have recently identified the HMG box transcription factor Sox-13 and described its expression during murine embryogenesis. Here we describe the structure of the murine Sox-IS gene. This gene spans approximately 12 kb and consists of 13 exons. The HMG domain is encoded by exons XI and XII, separated by an intron that is conserved among Sox-5, Sox-IS, and Sox-17. A single major transcription initiation site was identified. Deletion analysis of the 3-kb promoter region revealed a 400-bp fragment driving transcription of a luciferase reporter in a Sox-IS-expressing cell line. To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolated with 75% homology to the mouse Sox-IS. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32. (C) 1999 Academic Press. |
