| First Author | Geijsen N | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5532 | Pages | 1136-8 |
| PubMed ID | 11498591 | Mgi Jnum | J:114044 |
| Mgi Id | MGI:3688054 | Doi | 10.1126/science.1059157 |
| Citation | Geijsen N, et al. (2001) Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science 293(5532):1136-8 |
| abstractText | Cytokine receptors consist of multiple subunits, which are often shared between different receptors, resulting in the functional redundancy sometimes observed between cytokines. The interleukin 5 (IL-5) receptor consists of an IL-5-specific alpha-subunit (IL-5Ralpha) and a signal-transducing beta-subunit (betac) shared with the IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors. In this study, we sought to find a role for the cytoplasmic domain of IL-5Ralpha. We show that syntenin, a protein containing PSD-95/Discs large/zO-1 (PDZ) domains, associates with the cytoplasmic tail of the IL-5Ralpha. Syntenin was found to directly associate with the transcription factor Sox4. Association of syntenin with IL-5Ralpha was required for IL-5-mediated activation of Sox4. These studies identify a mechanism of transcriptional activation by cytokine-specific receptor subunits. |
