| First Author | Saftig P | Year | 1995 |
| Journal | EMBO J | Volume | 14 |
| Issue | 15 | Pages | 3599-608 |
| PubMed ID | 7641679 | Mgi Jnum | J:28201 |
| Mgi Id | MGI:75826 | Doi | 10.1002/j.1460-2075.1995.tb00029.x |
| Citation | Saftig P, et al. (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 14(15):3599-608 |
| abstractText | Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in a state of anorexia at day 26 +/- 1. An atrophy of the ileal mucosa first observed in the third week progresses towards widespread intestinal necroses accompanied by thromboemboli. Thymus and spleen undergo massive destruction with fulminant loss of T and B cells. Lysosomal bulk proteolysis is maintained. These results suggest, that vital functions of cathepsin D are exerted by limited proteolysis of proteins regulating cell growth and/or tissue homeostasis, while its contribution to bulk proteolysis in lysosomes appears to be non-critical. |
