| First Author | Lahtinen U | Year | 2003 |
| Journal | FEBS Lett | Volume | 538 |
| Issue | 1-3 | Pages | 85-8 |
| PubMed ID | 12633858 | Mgi Jnum | J:154845 |
| Mgi Id | MGI:4399033 | Doi | 10.1016/s0014-5793(03)00135-2 |
| Citation | Lahtinen U, et al. (2003) Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett 538(1-3):85-8 |
| abstractText | Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin-2 and disappearance of caveolae from the basolateral membrane. Correspondingly, in MDCK cells over-expressing caveolin-2 the basolateral membrane exhibited an increased number of caveolae. These results indicate the involvement of caveolin-2 in caveolar biogenesis. |
