| First Author | Takahashi C | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6017 | PubMed ID | 25598413 |
| Mgi Jnum | J:219725 | Mgi Id | MGI:5629622 |
| Doi | 10.1038/ncomms7017 | Citation | Takahashi C, et al. (2015) mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes. Nat Commun 6:6017 |
| abstractText | Cell fate specifications of multiciliate cells (MCCs) and ionocytes are commonly suppressed by the Notch pathway in developing epithelia, but are governed by different master regulators, suggesting the existence of a common regulator linking the Notch pathway to both MCC and ionocyte specifications. Here we show that a mab21 family gene, mab21-l3, represents the missing link. In Xenopus embryonic epidermis, mab21-l3 expression is specifically found in MCCs and ionocytes and is downregulated by the Notch pathway. Knockdown of mab21-l3 in Xenopus downregulates both MCC-specific and ionocyte-specific master genes, resulting in drastic loss of MCCs and ionocytes. In mouse tracheal epithelial cells, mab21-l3 expression is also downregulated by the Notch pathway and is required for MCC differentiation. Moreover, conditional gain of function of mab21-l3 rescues Notch-induced loss of MCCs and ionocytes in Xenopus. These results indicate that mab21-l3 acts downstream of the Notch pathway in cell fate specifications of MCCs and ionocytes. |
