| First Author | Zhu Y | Year | 2016 |
| Journal | J Exp Med | Volume | 213 |
| Issue | 2 | Pages | 167-76 |
| PubMed ID | 26755705 | Mgi Jnum | J:243463 |
| Mgi Id | MGI:5908517 | Doi | 10.1084/jem.20150785 |
| Citation | Zhu Y, et al. (2016) Identification of CD112R as a novel checkpoint for human T cells. J Exp Med 213(2):167-76 |
| abstractText | T cell immunoglobulin and ITIM domain (TIGIT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIGIT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112. In this study, we describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for human T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. We further identify that CD112, widely expressed on antigen-presenting cells and tumor cells, is the ligand for CD112R with high affinity. CD112R competes with CD226 to bind to CD112. Disrupting the CD112R-CD112 interaction enhances human T cell response. Our experiments identify CD112R as a novel checkpoint for human T cells via interaction with CD112. |
