| First Author | Smith DE | Year | 2003 |
| Journal | J Neurocytol | Volume | 32 |
| Issue | 3 | Pages | 293-303 |
| PubMed ID | 14724391 | Mgi Jnum | J:121345 |
| Mgi Id | MGI:3709822 | Doi | 10.1023/B:NEUR.0000010087.39779.f2 |
| Citation | Smith DE, et al. (2003) Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303 |
| abstractText | GABA-like immunoreactivity (GABA-LI) in the substantia nigra pars compacta (SNc) of mutant weaver mice was investigated at the electron microscope level. Eight-week-old homozygous mutant weaver mice, paired with wildtype littermates as controls, were perfused with a buffered paraformadehyde/acrolein solution. Sections containing the SN were immunocytochemically reacted with an antiserum to GABA using the peroxidase-antiperoxidase (PAP) procedure. Ultrastructural examination revealed that profiles of GABA-LI dendrites were decreased in number while profiles of labeled axonal processes were increased. In addition, there were an increased number of GABA-LI terminals in contact with similarly labeled GABA-LI dendrites. Double-labeling experiments using the antibodies to GABA and dopamine D(2) receptors showed that a small number of GABA-LI profiles exhibited D(2)-like immunoreactivity in both controls and weavers.These results suggest that the GABA-LI synaptic connections are altered as a result of the loss of DA neurons in the SNc of the weaver mice. |
