| First Author | Ohgoh M | Year | 2000 |
| Journal | Neurosci Lett | Volume | 288 |
| Issue | 3 | Pages | 167-70 |
| PubMed ID | 10889334 | Mgi Jnum | J:108034 |
| Mgi Id | MGI:3622875 | Doi | 10.1016/s0304-3940(00)01213-1 |
| Citation | Ohgoh M, et al. (2000) Apoptotic cell death of cerebellar granule neurons in genetically ataxia (ax) mice. Neurosci Lett 288(3):167-70 |
| abstractText | An autosomal recessive neurological mutant, ataxia (ax) mouse, was investigated to determine whether neuronal cell death occurs in the brain. The brains of homozygotes (ax(J)/ax(J)) and phenotypically normal littermates (ax(J)/+ or +/+) aged at 23-38 days were examined by the terminal dUTP nick-end-labeling (TUNEL) method. A few TUNEL-positive cells were observed in the granule cell layer of the cerebellum, the dentate gyrus, and the olfactory bulb of normal mice. In the affected mice, the number of TUNEL-positive cells was significantly increased in the cerebellum, particularly in the granule cell layer, compared to normal littermates. The findings suggest that ax mice will be useful as a model for studies on the genetic basis of apoptotic neuronal cell death. |
